Does Duet 2 (USB) work with Reason, Cubase or Ableton? Chris February 23, 2021 01:43 Updated Yes! Duet 2 works with Reason, Cubase, Ableton, or any other Core Audio application on the Mac. Related articles Duet 2 System Requirements Apogee Product Software & Firmware Versions List (Current Products) Duet (FireWire) vs. Duet 2 (USB) Comments 0 comments Article is closed for comments.