This is a normal message and does not indicate any problems. The output settings on your Apogee product are adjusted either using the physical controls on the unit, or via the Apogee Maestro or Control software.

Mac Sound Preferences

If your Apogee device is not recognized by the Apogee Maestro or Apogee Control software, it may be the software has not been allowed to run by Apple’s security controls in newer OS’s. See this article for more info: