Yes, if a microphone is connected to a Quartet Input and Speakers or Headphones are connected to Outputs FaceTime works correctly. Quartet must be selected to be the  Input and Output source for the Mac. This is done by opening the Apple Audio MIDI Setup Utility in the Utilities folder, Selecting the Quartet in the left column, then Right or Control Click on it and select “Use this device for Sound Input and Output “.  Alternatively this can be setup in System Preferences Sound page by selecting Quartet for Input and Output.